A potential alternative and less-invasive approach to measuring intracranial pressure (ICP) in traumatic brain injury patients has been reported.
ICP is a physiological variable that can increase abnormally when one has acute brain injury, stroke or obstruction to the flow of cerebrospinal fluid.
Symptoms of elevated ICP may include headaches, blurred vision, vomiting, changes in behaviour and decreased level of consciousness.
It can be life-threatening, hence the need for ICP monitoring in selected patients who are at increased risk.
However, the current standard for ICP monitoring is highly invasive: It requires the placement of an external ventricular drain (EVD) or an intraparenchymal brain monitor (IPM) in the functional tissue in the brain consisting of neurons and glial cells by drilling through the skull.
Study findings published by Johns Hopkins Medicine researchers suggest an alternative approach.
Director of anesthesiology and critical care medicine Robert Stevens explains: “ICP is universally accepted as a critical vital sign – there is an imperative need to measure and treat ICP in patients with serious neurological disorders, yet the current standard for ICP measurement is invasive, risky, and resource-intensive.
“Here we explored a novel approach leveraging Artificial Intelligence which we believed could represent a viable noninvasive alternative ICP assessment method.”
EVD procedures carry a number of risks including catheter misplacement, infection, and hemorrhaging at 15.3 per cent, 5.8 per cent, and 12.1 per cent, respectively, according to recent research. EVD and IPM procedures also require surgical expertise and specialised equipment that is not consistently available in many settings thus establishing a need for an alternative method in examining and monitoring ICP in patients.
The research team hypothesised that severe forms of brain injury, and elevations in ICP in particular, are associated with pathological changes in systemic cardiocirculatory function due, for example, to dysregulation of the central autonomic nervous system.
This hypothesis suggests that extracranial physiological waveforms can be studied to better understand brain activity and ICP severity.
In this study, the Johns Hopkins team set out to explore the relationship between the ICP waveform and the three physiological waveforms that are routinely captured in the ICU: invasive arterial blood pressure (ABP), photoplethysmography (PPG) and electrocardiography (ECG).
ABP, PPG and ECG data were used to train and contrast a panel of different deep learning algorithms, resulting in a level of accuracy in determining ICP that rivals or exceeds other methodologies.
Overall study findings suggest a completely new, noninvasive alternative to monitor ICP in patients.
Stevens says: “With validation, physiology-based AI solutions, such as the one used here, could significantly expand the proportion of patients and health care settings in which ICP monitoring and management can be delivered.”
