Parkinson’s
Cellular Intelligence has acquired global rights to Novo Nordisk’s clinical-stage cell therapy programme for Parkinson’s disease. As part of the agreement, Novo Nordisk will make an equity investment in Cellular Intelligence and will be eligible for future milestone payments and royalties. Cellular Intelligence said it aims to continue clinical development of the programme [...]
A non-surgical brain stimulation technique improved Parkinson’s movement symptoms in a small pilot study. The approach targets deep brain circuits from outside the skull, without the need to implant electrodes. Researchers said the early findings must be tested in larger studies before the technique can be considered for clinical use. The study, involving [...]
A brain switch tied to arousal and movement could help explain Parkinson’s symptoms and point to possible treatment approaches, new research suggests. Researchers say the mechanism may also offer clues for conditions linked to stress responses, including alcohol use disorder. The findings come from studies in mice, so more research is needed before any potential [...]
Human and fruit fly data have helped identify genes that may be risk factors or treatment targets in Parkinson's disease, a study suggests. The findings add to understanding of the endolysosomal pathway (ELP), the cell system that recycles and clears molecular waste, which has been increasingly linked to the toxic protein build-up seen in the [...]
Personalised Parkinson's treatments are a step closer after researchers identified distinct molecular subtypes of the disease. Using a machine learning-driven analysis, researchers identified two main groups and five subgroups, helping explain why a single treatment does not work for all patients. The findings could open the door to more targeted treatments for specific patient subgroups, [...]
A small molecule may slow Parkinson's progression by blocking harmful protein clumping in the brain, early research suggests. The treatment, known as SK-129, was designed to stop a neuronal protein building up and spreading between brain cells, a process linked to Parkinson's and related conditions. Those conditions include Lewy body dementia and multiple system atrophy, [...]
Distinct brain changes may help explain why some people with Parkinson's develop Parkinson's dementia while others do not. Researchers used detailed MRI scans to compare people with Parkinson's and dementia, people with Parkinson's but no dementia, and healthy controls. The findings suggest the brain changes linked to movement symptoms may be separate from those tied [...]
Gut microbes may help reveal Parkinson's risk years before symptoms appear, according to research. Researchers found signature changes in the gut microbiome, the community of bacteria living in the gut. The changes were more pronounced in people with a genetic risk of Parkinson's and more stark in those diagnosed with the disease. The signature could [...]
A new tool could improve Parkinson's diagnosis, helping doctors identify the disease faster and start treatment earlier. The Clinical Decision Support platform for Parkinson's Disease, or CDS-PD, uses machine learning, a form of AI that spots patterns in data, to support a physician's clinical decision-making in real time during a patient's visit with a Parkinson's [...]
Two Northumbria University researchers have won grants for Parkinson's disease and knee osteoarthritis projects in a £6.7m health research scheme. Dr Rodrigo Vitorio and Dr Justin Andrushko, both from Northumbria's School of Sport, Exercise and Rehabilitation, are among 55 early career scientists across the UK to receive funding from the Academy of Medical Sciences' Springboard [...]
