Dementia

Mild head injuries may raise Alzheimer’s risk later in life, but swift treatment after trauma could reduce the risk of Alzheimer’s and other long-term brain damage, new research suggests. Lab studies found a single mild traumatic brain injury can damage the brain’s lymphatic drainage system, the waste-clearing network that removes harmful proteins. In mice, repairing [...]

Risperidone raises stroke risk in all patients, research finds, challenging the idea that any group can take the drug without added danger. The study of more than 165,000 people with dementia found risperidone increased stroke risk even in patients with no prior heart disease or stroke. Risperidone is a strong antipsychotic often prescribed for severe [...]

US$1.04bn agreement for a novel investigational Alzheimer's therapy Biopharma company ADEL has announced that it has entered into an exclusive worldwide license agreement with Sanofi, a multinational healthcare company, for the development and commercialisation of ADEL-Y01. ADEL-Y01 is a potential first-in-class antibody therapy for Alzheimer's disease, and related backup compounds.   The total [...]

New research explains how a single mild brain injury can set off changes that increase the risk of Alzheimer’s disease. The discovery points to a possible way to prevent the disorder by repairing the brain’s drainage system after head trauma. Scientists found that traumatic brain injuries impair lymphatic vessels that connect the brain and the [...]

Scientists say breakdown of perineuronal nets around brain cells may explain why people with Alzheimer's forget loved ones. The findings could lead to new treatments using drugs already available for other conditions, researchers said. A devastating consequence of the disease is that patients forget even close family and friends. Exactly which brain changes drive this [...]

Risperidone raises stroke risk without exception in patients with dementia, according to researchers who analysed GP records. A study of 165,000 patients diagnosed with dementia after the age of 65 between 2004 and 2023 found stroke risk was increased even in those with no history of heart disease or stroke. Reporting their findings, researchers from [...]

NR Times explores the latest research developments in the world of neurology and neurorehabilitation.  Scientists reverse Alzheimer’s in mice using nanoparticles Researchers have demonstrated a nanotechnology strategy that reverses Alzheimer’s disease in mice. Unlike traditional nanomedicine, which relies on nanoparticles as carriers for therapeutic molecules, this approach employs nanoparticles that are bioactive in their own [...]

Traumatic brain injuries (TBI) in older adults are associated with a 69 per cent higher risk of developing dementia within five years, new research has found. The study analysed data from more than 260,000 adults aged 65 and older between April 2004 and March 2020, following them until dementia diagnosis, March 2021, or death. It [...]

Scientists have developed a molecule that prevents toxic protein clumping in Parkinson's disease, demonstrating its effect in an animal model. Researchers at the University of Bath, working with the Universities of Oxford and Bristol, engineered a peptide fragment that locks alpha-synuclein – a protein that forms toxic clumps in Parkinson's – into its healthy shape, [...]

A new brain imaging technique has detected tiny pulsing blood vessels that could reveal early Alzheimer's disease and track changes linked to ageing. Alzheimer’s disease is the most common form of dementia. It is currently the seventh leading cause of death and one of the major causes of disability in older people worldwide. The method [...]