Does gender and sexual orientation affect your stroke risk?

By Published On: 19 January 2023

A new study has examined whether individuals who identify as lesbian, gay, bisexual, transgender or non-binary have a higher risk of stroke at a younger age and also if there is a higher possible risk for recurrence than those who identify as straight and cisgender.

In this study, medical records of 26 stroke patients who identified as sexual and gender minorities were reviewed and then compared with 78 age-matched stroke patients who were not sexual and gender minorities.

Traditional stroke risks, such as smoking, hypertension and diabetes, were similar for both groups and it was found that the sexual and gender minority patients were more likely to have “none-traditional stroke risks.”

These non-traditional risks included HIV and current or previous history of syphilis and hepatitis C, conditions that can increase stroke risk as a result of inflammation and blockage of blood vessels.

Study senior author, Nicole Rosendale, MD, says: “While positivity rates were higher for substance abuse, as well as HIV, hepatitis C and syphilis for people in the sexual and minority group, they were more likely to be tested, which may account for them.”

Of the patients tested for HIV, 8 of the 23 (34.8 per cent) in the sexual and gender minority group were positive, versus none of the 36 patients in the non-minority group.

For hepatitis C, 4 of 14 (28.5 per cent) patients tested in the minority group had or had had the virus, compared with 4 of 19 (21 per cent) in the non-minority group.

Among those tested for syphilis, 5 of the 19 (26.3 per cent) had or had had syphilis in the minority group, versus none of 25 tested patients in the non-minority group.

The minority group also had a higher rate of substance use, itself a risk factor for all three conditions, with 11 of 18 (61.1 per cent) testing positive for substances in urine tests during their hospital admissions, compared with 19 of 556 (33.9 per cent) in the non-minority group.

Rosendale states that due to a limited number of minority patients in the study, researchers were unable to link specific subgroups to risks.

On the study findings, Rosendale says: “Previous studies have shown that the prevalence of HIV and syphilis is highest in transgender women, and in gay and bisexual cisgender men. Stroke risk appears to be higher in lesbian women than in straight women, with one study showing that they had higher rates of self-reported stroke.

“There may be many reasons for this – higher rates of smoking, higher prevalence of obesity, effects of discrimination on vascular health and limited access to health care.”

The average age of stroke patients at the study hospital was 69, the average age of the sexual and gender minorities group was 55.

The research team also discovered that the minority group was more likely to experience recurrent stroke, despite similar follow-up rates as the non-minority group, on this Rosendale says: “Future research will need to explore the drivers of recurrent stroke, including the role of minority stress. 

“Stigma, prejudice and discrimination create an inherently stressful environment that translates into health issues.”

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