Neurons in the spinal cord process pain signals differently in women compared to men, a new breakthrough study has found, which could lead to better and more personalised treatments for chronic pain.
Although it has long been known that women and men experience pain differently, most pain research uses male rodents.
The new study is unique because it used female and male spinal cord tissue from both rats and humans, which was donated by deceased individuals and their families.
By examining the spinal cord tissue in the laboratory, the researchers were able to show that a neuronal growth factor called BDNF plays a major role in amplifying spinal cord pain signalling in male humans and male rats, but not in female humans or female rats.
When female rats had their ovaries removed, the difference disappeared, pointing to a hormonal connection.
“Developing new pain drugs requires a detailed understanding of how pain is processed at the biological level,” said Dr Annemarie Dedek, lead author of the study and research fellow at Carleton University and The Ottawa Hospital.
“This new discovery lays the foundation for the development of new treatments to help those suffering from chronic pain.”
The study marks the first time a sex-related difference in pain signalling has been identified in human spinal cord tissue. Future studies are required to understand how this biological difference may contribute to differences in pain sensation between men and women.
The team’s pioneering work is also helping to bridge the gap between animal studies and new treatments for chronic pain.
The breakthrough in the new study was possible because of a unique collaboration between the research laboratories of:
- Dr Mike Hildebrand, associate professor at Carleton University and affiliate investigator at The Ottawa Hospital
- Dr Eve Tsai, neurosurgeon and Suruchi Bhargava chair in spinal cord and brain regeneration research at The Ottawa Hospital and associate professor at the University of Ottawa Brain and Mind Research Institute
- Dr Yves De Koninck, director of the CERVO Brain Research Center at Laval University
- Dr Jian Xu, associate research scientist, Yale University
