Anxiety cues have been found in the brain despite the person being in a safe environment, giving new insight into how the brain behaves in people with anxiety disorders.
Through a virtual reality-led study to reveal the impact of anxiety on the brain, and how brain regions interact with one another to shape behaviour, it was found that those with an anxiety disorder were unable to regulate their behaviour.
“These findings tell us that anxiety disorders might be more than a lack of awareness of the environment or ignorance of safety, but rather that individuals suffering from an anxiety disorder cannot control their feelings and behaviour even if they wanted to,” says Dr Benjamin Suarez-Jimenez, assistant professor in the Del Monte Institute for Neuroscience at the University of Rochester and first author of the study.
“The patients with an anxiety disorder could rationally say – I’m in a safe space – but we found their brain was behaving as if it was not.”
Using fMRI, the study observed the brain activity of volunteers with general and social anxiety as they navigated a virtual reality game of picking flowers.
Half of the meadow had flowers without bees, the other half had flowers with bees that would sting them – as simulated by a mild electrical stimulation to the hand.
Researchers found all study participants could distinguish between the safe and dangerous areas, but brain scans revealed volunteers with anxiety had increased insula and dorsomedial prefrontal cortex activation – indicating their brain was associating a known safe area to danger or threat.
“This is the first time we’ve looked at discrimination learning in this way. We know what brain areas to look at, but this is the first time we show this concert of activity in such a complex ‘real-world-like’ environment,” says Dr Suarez-Jimenez.
“These findings point towards the need for treatments that focus on helping patients take back control of their body.”
Understanding the neural mechanisms by which the brain learns about the environment is the focus of Dr Suarez-Jimenez’s research, particularly how the brain predicts what is threatening and what is safe.
He uses virtual reality environments to investigate neural signatures of anxiety disorders and post-traumatic stress disorder (PTSD).
His goal is to understand how people build maps in the brain that are based on experience, and the role of those maps in psychopathologies of stress and anxiety.
“For next steps in this recent research, we still need to clarify if what we found in the brain of these patients is also the case in other disorders, such as PTSD,” he adds.
“Understanding the differences and similarities across disorders characterised by deficits in behavioural regulation and feelings in safe environments, can help us create better personalised treatment options.”
