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Daily News Round Up: Wednesday, 27 March

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Welcome to your daily round-up of everything happening in the world of neurorehabilitation.

Research news

Brain pH changes linked to wide-ranging cognitive issues

A large-scale animal study has identified brain energy metabolism dysfunction leading to altered pH and lactate levels as common hallmarks in numerous animal models of neuropsychiatric and neurodegenerative disorders, such as intellectual disability, autism spectrum disorders, schizophrenia, bipolar disorder, depressive disorders, and Alzheimer’s disease.

New treatment target identified for Alzheimer’s disease

Researchers at the University of Leeds and Lancaster University in the UK have identified a new potential target for the treatment of Alzheimer’s disease – PDE4B. PDE4B is an enzyme inside cells that breaks down a molecule known as cyclic AMP, which regulates a range of cellular processes. Based on an Australian study that identified the PDE4B gene as a risk factor for developing Alzheimer’s disease, the UK team investigated whether reducing PDE4B activity might protect against Alzheimer’s disease pathology and be a useful treatment approach. To this end, they introduced a gene for reduced PDE4B activity into an Alzheimer’s disease mouse model that develops amyloid plaques in the brain, a key pathological feature of the disease.

More needs to be done for depressed stroke survivors as incidence climbs

Researchers say more needs to be done for depressed stroke survivors as new findings show 60% of stroke survivors would experience depression within 18 years, a much higher estimation than previous studies. This compares to 22% of the general population experiencing depression in the same time frame. The King’s College London study, published today in The Lancet Regional Health – Europe, also found 90% of cases of depression occurred within five years of surviving a stroke, indicating a key time for healthcare intervention.

Long-term consumption of reused deep-fried oil linked with increased neurodegeneration

A new study found higher levels of neurodegeneration in rats that consumed reused deep fried cooking oils and their offspring compared to rats on a normal diet. Deep frying, which involves completely submerging food in hot oil, is a common method of food preparation around the world.

Company and financial neuro-rehab news

First cohort dosed in pivotal study of LPCN 1154

SALT LAKE CITY, March 25, 2024 /PRNewswire/ — Lipocine Inc. (NASDAQ: LPCN), a biopharmaceutical company focused on treating Central Nervous System (CNS) disorders by leveraging its proprietary platform, today announced that study enrollment is complete and the first cohort of subjects has been dosed in pivotal pharmacokinetic (PK) study designed to support a New Drug Application (NDA) for LPCN 1154. LPCN 1154, oral brexanolone, is being developed by Lipocine for the treatment of postpartum depression (PPD). Oral LPCN 1154, comprising a bioidentical neuroactive steroid with 48-hour outpatient dosing, is being developed to provide rapid relief with robust efficacy.

Enrollment complete for PROSPECT Study of Tirabrutinib

ONO Pharmaceuticals, Co., Ltd. today announced it has completed target patient enrollment of the first arm of the PROSPECT Study, a Phase 2 clinical trial evaluating the safety and efficacy of tirabrutinib in U.S. patients with relapsed or refractory primary central nervous system lymphoma.

Policy, legislation and society news

Elaboration of a draft Recommendation on the Ethics of Neurotechnology

24 international experts will convene from 22 to 26 April 2024 at UNESCO Headquarters in Paris to start preparing a first draft of the Recommendation on the Ethics of Neurotechnology. Following the decision taken by the 194 Member States of UNESCO during the 42nd session of the General Conference held in November 2023, UNESCO Director-General Audrey Azoulay has convened a multidisciplinary group of 24 high-level experts geographically and gender balanced, also called the Ad Hoc Expert Group (AHEG), to prepare a first draft of the Recommendation on the Ethics of Neurotechnology.

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